Treatment-Adaptive vs Response-Adaptive Randomisation: A Practical Guide for Medtech Trials
Medical device trials increasingly incorporate adaptive randomisation to improve efficiency and patient outcomes. Two main approaches have emerged: treatment-adaptive randomisation (TAR), which modifies allocation probabilities at pre-planned interim analyses, and response-adaptive randomisation (RAR), which updates allocations continuously based on patient outcomes. The choice between these methods depends on trial characteristics including endpoint timing, data infrastructure, regulatory requirements, and scientific objectives.…